International Journal of
Medical Sciences
International Journal of Medical Sciences is an open access medical research journal covering various areas of basic medical sciences and clinical research related to the studies of human diseases. Articles include original research papers, reviews and short research communications. The Journal aims at rapid publication of high quality medical research results while maintaining rigorous peer review process. Full texts of published articles appear in PubMed Central, the U.S. National Institutes of Health (NIH) digital archive of biomedical journal literature, and abstracts are indexed in PubMed.
Editor-in-Chief: Dr. Dennis D. Taub of Laboratory of Immunology, National Institute on Aging, NIH.
Now indexed in MEDLINE
VEGF T-1498C polymorphism, a predictive marker of differentiation of colorectal adenocarcinomas in Japanese
Motohiro Yamamori, Mayuko Taniguchi, Shingo Maeda, Tsutomu Nakamura, Noboru Okamura, Akiko Kuwahara, Koichi Iwaki, Takao Tamura, Nobuo Aoyama, Svetlana Markova, Masato Kasuga, Katsuhiko Okumura, Toshiyuki Sakaeda
Full text in PubMed Central ensures that
your article will be properly rendered and permanently available for
readers of many generations to come.
Medsci.orgBackground: Previously, MDR1 T-129C polymorphism, encoding multidrug resistant transporter MDR1/P-glycoprotein, was reported to be predictive of poorly-differentiated colorectal adenocarcinomas. Here, VEGF T-1498C, C-634G and C-7T polymorphisms, encoding vascular endothelial growth factor (VEGF), were investigated in terms of their association
...
Expression and function of micro RNAs in immune cells during normal or disease state
Esmerina Tili, Jean-Jacques Michaille, George Adrian Calin
Micro RNAs (miRNAs) are 19-24 nucleotide long non-coding RNAs that posttranscriptionally modulate gene expression. They are found in almost all species: viruses, plants, nematodes, fly, fish, mouse, human, and are implicated in a wide array of cellular and developmental processes. Microarray-based miRNA profiling brought to the discovery of miRNAs
...
Principal Investigator Views of the IRB System
Simon N. Whitney, Kirsten Alcser, Carl E. Schneider, Laurence B. McCullough, Amy L. McGuire, Robert J. Volk
We undertook a qualitative e-mail survey of federally-funded principal investigators of their views of the US human subjects protection system, intended to identify the range of investigator attitudes. This was an exploratory study with a 14% response rate. Twenty-eight principal investigators responded; their comments were analyzed to show
...
A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy
Basir Tareen, Jack L. Summers, James M. Jamison, Deborah R. Neal, Karen McGuire, Lowell Gerson, Ananias Diokno
Purpose: To evaluate the safety and efficacy of oral Apatone® (Vitamin C and Vitamin K3) administration in the treatment of prostate cancer in patients who failed standard therapy. Materials and Methods: Seventeen patients with 2 successive rises in PSA after failure of standard local therapy were treated with (5,000 mg of VC and 50 mg of VK3
...
Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization
Eberhard Grube, Andreas Bootsveld, Lutz Buellesfeld, Seyrani Yuecel, Joseph T Shen, Michael Imhoff
Background: Resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD), where patients with a history of coronary revascularization may pose special challenges. Several methods exist to enhance sensitivity and specificity of resting ECG for diagnosis of CAD, but such methods are not
...
Qualitative Dosimetric and Radiobiological Evaluation of High – Dose – Rate Interstitial brachytherapy Implants
Than S. Kehwar, Syed F. Akber, Kamlesh Passi
Radiation quality indices (QI), tumor control probability (TCP), and normal tissue complication probability(NTCP) were evaluated for ideal single and double plane HDR interstitial implants. In the analysis, geometrically–optimized at volume (GOV) treatment plans were generated for different values of inter–source–spacing (ISS)
...
Correlation of the Radiographic and Morphological Features of the Dental Follicle of Third Molars with Incomplete Root Formation
David Moraes de OLIVEIRA, Emanuel Sávio de Souza ANDRADE, Márcia Maria Fonseca da SILVEIRA, Igor Batista CAMARGO
The objective of this study was to determine the correlation of the radiographic and morphological features of the dental follicle of unerupted third molars with incomplete root formation. A cross-sectional study was carried out with 56 patients (105 teeth) aged 13 to 24 years. Panoramic radiography was used to determine the stage of root
...
Association Study of Aromatase Gene (CYP19A1) in Essential Hypertension
Masanori Shimodaira, Tomohiro Nakayama, Naoyuki Sato, Kosuke Saito, Akihiko Morita, Ichiro Sato, Teruyuki Takahashi, Masayoshi Soma, Yoichi Izumi
Background: As aromatase-deficient mice, which are deficient in estrogens, reportedly have reduced blood pressure, the aromatase gene (CYP19A1) is thought to be a susceptibility gene for essential hypertension (EH). The aim of the present study was to investigate the relationship between CYP19A1 and EH by examining single nucleotide polymorphisms
...
Physical Exercise and Quality of Life in Breast Cancer Survivors
Marco VALENTI, Giampiero PORZIO, Federica AIELLI, Lucilla VERNA, Katia CANNITA, Renato MANNO, Francesco MASEDU, Paolo MARCHETTI, Corrado FICORELLA
An important goal for cancer patients is to improve the quality of life (QOL) by maximising functions affected by the disease and its therapy. Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer survivors. Research has provided preliminary evidence for the safety, feasibility, and efficacy of
...
Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema
Pedro J Modrego, Beatriz Boned, Juan J Berlanga, Mercedes Serrano
OBJECTIVE. Plasmatic B-type-natriuretic peptide (NT-PBNP) and C-reactive protein (CRP) have been reportedly elevated in stroke patients; however their clinical significance remains uncertain. The purpose of this work is to investigate whether elevation of these proteins at baseline predicts CT-evidence of brain edema. METHODS. We recruited 41
...
Does eGFR improve the diagnostic capability of S-Creatinine concentration results? A retrospective population based study
Anders Kallner, Peter A Ayling, Zahra Khatami
The use of MDRD-eGFR to diagnose Chronic Kidney Disease (CKD) is based on the assumption that the algorithm will minimize the influence of age, gender and ethnicity that is observed in S-Creatinine concentration and thus allow a single cut-off at which further diagnostic and therapeutic actions should be considered. This hypothesis is tested in a
...
Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages
D. Shane O'Mahony, Uyenvy Pham, Ramesh Iyer, Thomas R. Hawn, W. Conrad Liles
No more wait for lengthy publication time in other journals only to find that
other researchers/labs have published the same results. Submit your manuscripts
today.
Medsci.orgHuman Toll-like receptors (TLRs) comprise a family of proteins that recognizes pathogen-associated molecular patterns (PAMPs) and initiates host innate immune responses. Neutrophils, monocytes, and macrophages are critical cellular components of the human innate immune system. Proinflammatory cytokines, such as granulocyte colony-stimulating
...Retrived on 9 May 2008 19:41:35 EDT