International Journal of Medical Sciences Volume 1
An Accurate Confirmation of Human Immunodeficiency Virus Type 1 (HIV-1) and 2 (HIV-2) Infections with a Dot blot assay Using Recombinant p24, gp41, gp120 and gp36 Antigens
Mehrdad Ravanshad, Farzaneh Sabahi, Fereidoun Mahboudi, Mohammad Hassan Roostaee, Ramin Sarami Forooshani, Anoshiravan Kazemnejad
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Medsci.orgAn immunoblot assay using four recombinant proteins corresponding to human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) gene products was developed to confirm the presence of antibodies to HIV-1 and 2 in sera reactive in screening ELISAs. Serum samples for testing were obtained from healthy seronegative blood donors and from different
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Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects
Mohamed El-Sammak, Mona Kandil, Safaa El-Hifni, Randa Hosni, Mahmoud Ragab
This study aimed to evaluate the plasma homocysteine (tHcy) and folate levels as well as the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Egyptian subjects. Fasting total homocysteine (tHcy) and the (MTHFR) C677T mutation were evaluated in 50 healthy young control males (age 35-50 years, Gp1), 50 elderly males age ranged between
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A review of anatomical and mechanical factors affecting vertebral body integrity
Andrew M Briggs , Alison M Greig, John D Wark, Nicola L Fazzalari, Kim L Bennell
Background: The aetiology of osteoporotic vertebral fracture is multifactorial and may be conceptualised using a systems framework. Previous studies have established several correlates of vertebral fracture including reduced vertebral cross-sectional area, weakness in back extensor muscles, reduced bone mineral density, increasing age, worsening
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Comparative study of serum Na+ and K+ levels in senile cataract patients and normal individuals
Mansour Mirsamadi, Issa Nourmohammadi, Manuchehr Imamian
Many factors such as aging, changes in blood electrolytes levels, and possibly family history are involved in senile cataract formation. Changes in serum electrolytes levels can induce changes in aqueous electrolytes levels and effect on lens metabolism and probably cataract formation. In this paper, we study serum level of Na+ and K+ in senile
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An Increased Risk of Osteoporosis during Acquired Immunodeficiency Syndrome
N. Annapoorna, G.Venkateswara Rao, N.S. Reddy, P. Rambabu, K.R.S.Samabasiva Rao
Osteoporosis is characterized by decreased bone mineral density and mechanistic imbalances of bone tissue that may result in reduced skeletal strength and an enhanced susceptibility to fractures. Osteoporosis in its most common form affects the elderly (both sexes) and all racial groups of human beings. Multiple environmental risk factors like
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Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus
Flávio Juliano Garcia Santos Pimenta, Maria das Graças Rodrigues Pinheiro, Ricardo Santiago Gomez
Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA
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Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice
Vivian Yvonne Shin, Wallace Hau-Leung So, Edgar Shiu-Lam Liu, Ying-Jye Wu, Shiu-Fun Pang, Chi-Hin Cho
Natural botanical products can be integrated with western medicine to optimize the treatment outcome, increase immune function and minimize the side effects from western drug treatment. CKBM is a combination of herbs and yeasts formulated based on traditional Chinese medicinal principles. Previous study has demonstrated that CKBM is capable of
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HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
Sara E Perry, Sobhy M Mostafa, Richard Wenstone, Alan Shenkin, Paul J McLaughlin
Low surface HLA-DR expression is a feature in sepsis. However, the mechanisms that regulate HLA-DR expression have not been elucidated. The current study investigates regulation of HLA-DR gene transcription, post transcriptional events and shedding of surface HLA-DR, as well as the regulation of HLA-DR by GM-CSF and an immunomodulatory cytokine.
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A Randomized Study of Epithelial Ovarian Cancer: Is Chemotherapy Useful after Complete Remission?
M. O. Nicoletto, S. Tumolo, C. Falci, M. Donach, E. Visonà, A. Rosabian, O. Nascimben, G.P. Cima, O. Vinante, P. Azzoni, M.V. Fiorentino
Objective. The aim of this study is to verify whether consolidation chemotherapy with Cisplatin improves disease-free survival and/or overall survival in patients affected by epithelial ovarian cancer. Methods. A multicenter study examined 122 randomized patients in complete remission as judged by laparoscopy or laparotomy following first-line
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Tyrosine kinase – Role and significance in Cancer
Manash K. Paul, Anup K. Mukhopadhyay
Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly
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Clinical Profiles of Chronic Hepatitis C in a Major County Medical Center Outpatient Setting in United States
Ke-Qin Hu, Huiying Yang, Ying-Chao Lin, Karen L Lindsay, Allan G Redeker
The estimated prevalence of hepatitis C virus (HCV) infection in the US is 1.8 %. Data are limited on the clinical profile of the disease at first presentation and dynamic follow-up of ALT level, especially in publicly-funded patients. This information is critical for optimal management of these patients. The present study is aimed to assess the
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Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline
Kevin R. Smith
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Medsci.orgThe theoretical possibility of applying gene transfer methodologies to the human germline is explored. Transgenic methods for genetically manipulating embryos may in principle be applied to humans. In particular, microinjection of retroviral vector appears to hold the greatest promise, with transgenic primates already obtained from this approach.
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Monte Carlo Commissioning of Low Energy Electron Radiotherapy Beams using NXEGS Software
Joseph A. Both, Todd Pawlicki
This work is a report on the commissioning of low energy electron beams of a medical linear accelerator for Monte Carlo dose calculation using NXEGS software (NXEGS version 1.0.10.0, NX Medical Software, LLC). A unique feature of NXEGS is automated commissioning, a process whereby a combination of analytic and Monte Carlo methods generates beam
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The primary prevention of birth defects: Multivitamins or folic acid?
Andrew E. Czeizel
Periconceptional use of folic acid alone or in multivitamin supplements is effective for the primary prevention of neural-tube defects. The Hungarian randomized and two-cohort controlled trials showed that periconceptional multivitamin supplementation can reduce the occurrence of some other structural birth defects, i.e. congenital abnormalities.
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Cribriform-Morular Variant of Papillary Carcinoma: Association with Familial Adenomatous Polyposis - Report of Three Cases and Review of Literature
Shylashree Chikkamuniyappa, Jaishree Jagirdar
We describe a rare variant of papillary thyroid carcinoma (PTC), the Cribriform-Morular Variant (C-MV). A handful of cases have been described in the literature of this entity. They exhibit the morphologic features of a distinctive papillary neoplasm along with solid, cribriform, and squamoid-morular areas. The cribriform and morular features make
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The Syndrome of Frontonasal Dysplasia, Callosal Agenesis, Basal Encephalocele, and Eye Anomalies – Phenotypic and Aetiological Considerations
Antonio Richieri-Costa, Maria Leine Guion-Almeida
We report ten sporadic cases of Brazilian patients with facial midline defects, callosal agenesis, basal encephalocele, and ocular anomalies. This very rare cluster of anomalies has been well reported before. However, only until recently it is recognized as a syndrome belonging to frontonasal dysplasia spectrum. The ten cases confirm a distinct
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Study of the early steps of the Hepatitis B Virus life cycle
Xuanyong Lu, Timothy Block
Hepatitis B virus (HBV) is a human pathogen, causing the serious liver disease. Despite considerable advances in the understanding of the natural history of HBV disease, most of the early steps in the virus life cycle remain unclear. Virus attachment to permissive cells, fusion and penetration through cell membranes and subsequent genome release,
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Discriminating between elderly and young using a fractal dimension analysis of centre of pressure
Tim L. A. Doyle, Eric L. Dugan, Brendan Humphries, Robert U. Newton
The aim of this project was to evaluate the use of a new analysis technique, fractal dimension analysis, for quantification of quiet stance centre of pressure (COP). By using a fractal dimension analysis of COP, it might be possible to gain more information about control during quiet stance than traditional analyses have previously allowed. The
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Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS)
Arthur Chun-Wing LAU, Loretta Yin-Chun YAM, Loletta Kit-Ying SO
Severe acute respiratory syndrome (SARS) is frequently complicated with acute respiratory failure. In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. Most SARS patients would require high flow oxygen supplementation, 20–30% required intensive care unit (ICU) or high dependency care,
...Retrived on 17 May 2008 12:57:38 EDT